Liverpool handed new manager Juergen Klopp his first Premier League win, coming from behind to beat defending champion Chelsea 3-1.
The defeat increased the pressure on Chelsea manager Jose Mourinho, whose side has now lost six of its opening 11 league matches.
Ramires opened the scoring for Chelsea as early as the 4th minute at Stamford Bridge but Liverpool hit back when Philippe Coutinho equalized in first-half stoppage time and then put the visitors ahead in the 74th. Christian Benteke got a third in the 83rd.
Chelsea has only 11 points from 11 matches.
Mourinho has made it clear he will not resign - while Chelsea's board delivered very public backing to their manager in early October.
Since then, however, Chelsea have barely improved and this comprehensive defeat comes on top of the acrimonious loss at West Ham United last weekend and the Capital One Cup exit against Stoke City on penalties in midweek.
And Mourinho, normally so confident and upbeat, carried the air of a beaten man as he stood hands in pockets on the touchline in the closing seconds with defeat assured and Stamford Bridge emptying rapidly.
Mourinho appeared distracted by opposite number Jurgen Klopp's constant, animated dialogue with fourth official Lee Mason, seeming to question what would happen if he acted in a similar fashion.