Vice President Kwesi Amissah-Arthur on Tuesday left Accra for Bamako, Mali.
Mr Amissah-Arthur is visiting Mali to express the condolence of the Government and people of Ghana, following the Radisson Blu Hotel attack in Bamako last week.
More than twenty people died when Mali's Special Forces and international partners freed 170 guests who were held hostage at their hotel by gunmen.
On Monday, Benin's President Thomas Boni Yayi and Burkina Faso's Prime Minister Yacouba Isaac Zida visited Mali to express their condolence.
Ghana and Mali have long historic ties.
Foreign affairs and regional integration minister Hanna Tetteh has said no Ghanaian dies in the attack.