Man United are out of the Champions League after defeat to Wolfsburg and head for the Europa League, while Man City go through as group winners.
Manchester United suffered an early exit from the Champions League as they were beaten by 3-2 by Wolfsburg.
United threw away an early lead and ultimately slipped from second to third in Germany as PSV moved into the top two behind Dieter Hecking's group winners - themselves battling back from Sergei Ignashevich's penalty to claim maximum points against CSKA Moscow.
Elsewhere, Raheem Sterling celebrated his 21st birthday with a quickfire double to send Manchester City through to the Champions League last 16 as group winners.
The England international struck twice in the space of two minutes as City came from behind to beat Borussia Monchengladbach 4-2 at the Etihad Stadium.
City had trailed after the Germans replied to David Silva's early strike through Julian Korb and Raffael but Sterling turned the game around late in the second half and Wilfried Bony added the final gloss.
With Juventus losing at Sevilla, the result was enough for City to leapfrog the Italians to the top of Group D while Monchengladbach slipped to the bottom and missed out on a Europa League spot.
Real Madrid also won 8-0 against Malmo. Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid thrashedMalmo 8-0 to equal the highest-ever victory in the Champions League.
Ronaldo netted four times and Mateo Kovacic was also on the score sheet as the 10-time European Cup winners ran riot at the Bernabeu, matching the figures set by Liverpool in December 2007 when they beat Besiktas by the same score.
Rafael Benitez having the distinction of being the manager on both occasions.